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Potential confoundersWe adjusted the risk estimates for comorbid clinical conditions, measured before the index date, known to be associated with acute kidney injury, which could also influence the choice of antihypertensive and NSAID treatment. We thus adjusted all models for the indication for antihypertensive drug use (hypertension, heart failure, and coronary heart disease measured at cohort entry), rhythm disorders, valvular disease, diabetes, number of hospital admissions (any time before the index date), excessive alcohol use, smoking status, and body mass index (all based on the last measure before the index date).6 https://en.wikipedia.org/wiki/Louis_Vuitton 7 22 29 30 31 To minimise the effect of severity of hypertension, we also adjusted the models for the blood pressure value recorded at cohort entry. We defined hypertension as “mild” when systolic or diastolic blood pressure was between 140 and 159 mm Hg or 90 and 99 mm Hg, “moderate” when systolic or diastolic blood pressure was between 160 and 179 mm Hg or 100 and 109 mm Hg, and “severe” when they were 180 mm Hg or 110 mm Hg or higher.16 Finally, we also adjusted the models for the use of other antihypertensive drugs ( blockers, blockers, and calcium channel blockers), digoxin, clopidogrel, anti arrhythmics, statins, antibiotics, immunosuppressive drugs, paracetamol, and corticosteroids, all measured in the year before the index date.
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